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Gene Transcription and Therapeutic Intervention

Cambridge Healthtech Institute chi at healthtech.com
Sat Jan 18 14:32:56 EST 1997

If you wish to receive more information please contact:

Cambridge Healthtech Institute
1037 Chestnut Street
Newton Upper Falls,  MA 02164

Phone: 617-630-1300
Fax: 617-630-1325
E-mail: chi at healthtech.com

Gene Transcription and Therapeutic Intervention
June 2-3, 1997
The Loews L’Enfant Plaza, Washington D.C.

Regulation of gene transcription lies in the heart of signal 
transduction process.  Changes in cell behavior during health 
and disease induced by growth factors or cytokines, require 
execution of selective gene transcription.  Significant progress 
has been made in our understanding of how extracellular or 
intracellular signals can regulate sets of genes in a selective 
fashion.  Cloning and identification of novel transcription factors 
(from genomics projects) gives us the opportunity for developing 
pioneering therapeutic approaches.  Development of agents that 
regulate gene expression represent a new and unexploited area 
for small molecule therapeutics. Selective regulation of transcription

with small molecules will emerge as a dominant gene therapy mode 
in 21st century.

This conference brings together leaders in the field of transcription 
regulation, both from academia and industry.  First session deals with

basic aspect of signal transduction, gene regulation and its 
importance in drug development.  Enormous progress has been made 
in nuclear receptor function and how they are used as models for 
transcription factors-drug interaction.  Sessions are also planned 
that discuss roles of specific transcription factors in diseases, for 
example, cancer, cardiovascular disease and inflammation.  Pathogen 
transcription apparatus is discussed as a therapeutic target from 
fungal and bacterial and viral perspective.  A full session is devoted

to exciting development from genomics and its impact in generation of 
transcription factors as drug targets. 

Signal Transduction and Transcription Regulation
Regulation of Transcription:  An Emerging New Area for Therapeutic
	Dr. Tauseef R. Butt, Gene Transcription Technologies; University of 
	Pennsylvania School of Medicine (confirmed)
In Vivo and In Vitro Analyses of the hsp70 Heat Shock Gene Promoter in

	Dr. David S. Gilmour, The Pennsylvania State University (confirmed)
Lac Repressor:  A Model Transcription Factor with Fascinating
Regulatory Modes of Action
	Dr. Mitch Lewis, University of Pennsylvania Medical School
Activation of Latent Transcription Factors in Response to Signal 
	Dr. Joseph Didonato, University of California School of Medicine

Nuclear Receptors as Model Transcription Factors
Human Estrogen Receptor:  A Rich History of a Receptor With Multiple 
Physiological Effects
	Dr. Leslie Pike, University of Cincinnati
Nuclear Receptor Coregulatory Proteins:  A New Frontier of Hormone 
Action and Transcriptional Regulation
	Dr. Paul G. Walfish, University of Toronto Medical School and Mount 
	Sinai Hospital(confirmed)

Androgen Receptor and Co-activator Interaction
	Dr. Chawshang Chang University of Wisconsin
Expression of PPARs and Their Role in Physiology
	Dr. Walter Wahli, University of Lausanne

Emerging Concepts and Bioinformatics Approaches  in Transcription 
Regulation Advanced Data Management Tools for the Study of Gene 
	Dr. G. Christian Overton, University of Pennsylvania (confirmed)
Patterns of Gene Expression: A Bioinformatics Approach to Identifying 
Master Transcription Regulators 
	Dr. Frank Tobin, SmithKline Beecham Pharmaceuticals (tentative)
Gene Expression Micro-Arrays:  A New Tool for Genomics
	Dr. Deval A. Lashkari, Synteni, Inc. (confirmed)
Sequencing and Analysis of Human Regulatory Regions
	Dr. Marc Vasseur, Genset (confirmed)
Transcription Regulation:  The Other End of Gene Therapy Challenge
	Dr. Inder Verma, The Salk Institute

Transcription Factors, Apparatus and Therapeutic Intervention
Rapid Screening of DNA Binding Molecules in Developing Small Molecule 
Gene-regulating Drugs
	Dr. Cynthia Edwards, Genelabs Technologies, Inc.
Microbial Transcription Apparatus as a Novel Antimicrobial Drug Target
	Dr. C. Richard Wobbe, Scriptgen Pharmaceutical (confirmed)
Activation of RXR Pathway Modulates Apoptosis in Myeloid and Lymphoid 
	Dr. Richard A. Heyman, Ligand Pharmaceuticals
E2F Transcription Factor as Anticancer Targets
	Dr. Roberto Wienman, Bristol-Myers Squibb Pharmaceutical Research 
	Institute (confirmed)
Topic to be Determined
	Dr. David Kirn, Onyx Pharmaceuticals
	Oncogene Sciences, Inc.
Regulation of HDL Gene Expression and Cardiovascular Function
	Dr. Sotirios K. Karathanasis, Wyeth-Ayerst Research (confirmed)
Peroxisome Proliferator Receptor Modulating Drugs and Their Role in 
the Treatment of Non-Insulin Dependent Diabetes
	Dr. Paul Young, SmithKline Beecham Pharmaceuticals (confirmed)
Therapeutic Intervention of Cytokine Signaling:  Molecular Targets and

Screening Strategies
	Dr. Casey C. Case, Tularik, Inc. (confirmed)
Complex Regulation of NF-Kappa B During the Inflammatory Response
	Dr. Steven M. Taffet, State University of New York Health Science 
	Center at Syracuse (confirmed)
NF-AT Family of Transcription Factors and Cytokine Gene Regulation
	Dr. Anjana Rao, Harvard Medical School

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